Hydrocel HPMC / Hypromellose cellulose ethers are water soluble polymers derived from cellulose ethers that are derived from cellulosic materials such as natural wood or cotton linters. Hydrocel HPMC offer some exceptional range of properties which makes it a key component in pharmaceutical formulations, dermaceutical and topical products as well as the personal care and food industry.
In the recent years, with our ever increasing want to improve our quality and consistency we have made further advances in understanding this polymer and its matrix system have for its application in more controllable and reproducible drug release profile by working on its properties and making the parameters more stringent. Hydrocel-CR (Hypromellose) is especially suitable for this application, and provides a genuine consistency in the final products.
Cellulose derivatives such as HPMC, which when comes into contact with water forms a matrix system which makes it popular for use in controlled release dosage forms for modulating drug release in tablets and pellets. HPMC matrices follow 2 mechanisms i.e diffusion through the swelling layer and release by matrix erosion of the swollen layer.
The steps of Sustained release through Hydrophilic Matrix Systems is as follows: